Acute toxicity study of hydroalcoholic extract of two Indian medicinal plants Alternanthera ficoidea and Ludwigia octovalvis

Background: The ethano-pharmacological survey on two Indian medicinal plants Alternanthera ficoidea and Ludwigia octovalvis revels that both are biologically potential effective in the management of various diseases. Despite as whole used traditionally by local people subcontinent but toxicity studies plant extract has not explored scientifically. Objective: study was designed to explore associated hydroalcoholic according OECD guidelines. Material methods: Healthy Charles Foster albino female rats 8-12 weeks’ old were divided 3 groups. Group I, group II, III received vehicle (0.5% CMC, p.o., single dose), (HAF) (Single dose 2000 mg/kg, given orally), (HLO) respectively. After 14 days, all anesthetized with chloroform blood collected retro-orbital capillary puncture for haematological biochemical parameters. collection, sacrificed; organs carefully collected, weighted examined changes. Results: acute foster showed there no sign symptoms seen group. Haematological parameters, parameters histopathological architectures treated groups found be non-significant normal range when compared control Conclusion: mortality occurred at a dosage 2 g/kg HAF HLO, it came conclusion IC50 HLO higher than level.